Goodbye to Ficks law

It has always been  assumed but never proven that iCMR gives an incremental value by providing more accurate flow quantification. In  Dallas Childrens/UTSW interventional MRI is now standard procedure in young adults. Therefore they conducted a study in 30 patients with CHD and conducted both right and left heart cath at a success rate of multiple data points of 98 %. In doing the study the Dallas team  validates hemodynamic measurements obtained via iCMR and showed that iCMR-derived flows have considerably higher test–retest reliability for Qs. iCMR evaluations allow for more reproducible hemodynamic assessments in the CHD population. Goodbye to Fick’s law in CHD

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Satellite webinar-May5th 2021

At the upcoming 12th meeting on Adult Congenital Heart Disease (EuroGUCH 2021) meeting we are organizing an webinar as satellite symposium on May 5th at 12 o’clock CET. The webinar is entitled “MRI guided procedures- lessons from pediatric cardiology”. During the 30 min symposium prof. Ewert (German heart centre Munich) will explain his center journey into MRI hemodynamics and its current use. Subsequently, Dr Suren Reddy (UTSW-Dallas Children’s) will show the recent advances made in the field of interventional MRI in single ventricle patients. . We are happy to welcome you during the meeting. As was noted by dr Thomas Krasemann (Rotterdam) as comment to our LinkedIn post ” Important to realize how many procedures were pioneered in Pediatric Cardiology (i.e. transcatheter valves, balloon valvoplasties, certain stent procedures, devices…). We are dealing with orphan diseases and hence have the need to be creative. To protect our vulnerable patients we try to reduce radiation use whenever we can. Again, MRI guided interventions for structural cardiac problems have been pioneered in Pediatrics. Great that the title of this seminar already acknowledges this! “

 

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Countdown to SCMR

Tomorrow starts the SCMR symposium, for the first time online. Remember that last year on February 14th 2020, the first interventional live case was shown from Dallas Children’s using our guidewire for a valvular angioplasty. Curious what this year’s meeting will bring? Listen to prof. Gerry Greil from Dallas UTSW.

Gerald Greil, SCMR Program Committee Member, invites you to the SCMR Virtual Scientific Sessions. Of course  we all miss speaking directly with all our friends and colleagues in-person to discuss about all the new and exciting developments in cardiac MRI to diagnose and treat heart disease from fetal life to adulthood. As part of the the congenital heart disease program group, he would like to make you particularly aware of the Congenital Heart Disease Pre-Conference Course.

 

 

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Proud to receive ECR award

Over the past months the research projects we are involved in, are popular in awards. I guess a recognition for the work done in collaboration with our partners such as Fraunhofer MEVIS, UKSH, Dallas Childrens and many others. Most recently the work to extend our MagnaFy technology to visualize instruments both in MRI and MPI (Magnetic Particle Imaging) within the IMAGINE project was awarded the best research presentation abstract at the European Congress of Radiology2021. Although MPI is still a long way from clinical application, our technology will help to advance its implementation in the future.

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The upside of lockdown

2020 was a year when many things changed in the world and of course also to Nano4Imaging. We started the year with high hopes of successfully launching the EmeryGlide in the USA. However, the pandemic turned everything upside down. Just before that there was the first live case with interventional MRI at SCMR-Orlando out of Dallas Children’s/UTSW, and at the end of the year a 3-years shelf life extension. After the massive global lockdown we were able to secure our financial stability and at the same time have been able to brainstorm a new way forward or a new company role in interventional MRI.

Since many clinical teams had to interrupt their routine and had time to discuss and think about the future and new applications of interventional MRI, we had the opportunity to brainstorm during Zoom, Teams and all the other program-sessions about needs and opportunities. Both existing and new clinical relationships contributed in developing a vision how standard clinical interventions in adults such as angioplasty, aneurysm repair and EVAR could be be enabled in MRI. Meanwhile several project applications with new and renowned partners such as AMC Amsterdam, RUMC Nijmegen, CHIV Lausanne and UKSK in Kiel.

We also realize that many of you have been directly or indirectly affected by COVID-19 and would like to share our thoughts and feelings in this period which has been and is still challenging us on a global level. Wish you relaxing Xmas days with your beloved and hoping to “see” you soon in 2021,

 

 

 

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Interventional MRI: the future

Several events in past weeks demonstrated that MRI is both a new kid on the block as well as serious party for the future. During PICS in Boston (September 13th 2020) dr Alain Nugent (Chicago, Lurie’s Children’s) stated that in 20 years MRI is the standard in the cathlab. The comparison he made was with the Iphone: nobody had one until 15 years ago! His arguments were clear and concerned the absence of radiation, visibility of the target tissue and superior flow measurement by MRI. Early October 2020 during ESMRMB Daniel Hoinkiss received a certificate of Merit award for his poster presentation  which originated from our Eurostars-SPECTRE and used animal data generated in Dallas Children’s by dr Suren Reddy and his team. Even in difficult pandemic times progress is made in our interventional dream.

PICS-2020-Nugent

 

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Full MRI session at PICS Boston 2020

So excited that for the first time in PICS history, a full session was dedicated today (september 13th) on interventional MRI in cardiac interventions. Great talks by @ Toby Rogers, @Robert Lederman, @Alan Nugent and @Aimee Armstrong on recent development and a 20 year look forward from now on this topic. Earlier today @Suren Reddy showed a taped case from Dallas Childrens. It was Toby Rogers from Washington Childrens showing a nice review of recent studies in CMR and good to see that two major centres in London (dr Dan Knight) and Dallas (dr Suren Reddy) using our EmeryGlide have now become reference centers for training, economics of MRI interventions and moving this to the next decade. As Alan Nugent said in his closing remarks: “it is simply too important and too relevant” no to do this..

 

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Dallas interventional work in complex CHD now in JCMR

It takes time to publish during clinical routine, but finally the groundbreaking work of the team by drs Reddy, Hussain and Greil at Dallas Children’s/UTSW is now published in JCMR. The study describes interventional CMR procedures successfully performed to completion in 31/34 (91%) subjects between August 1st 2017 to December 13th, 2018. Median age and weight of mostly (n=21) single ventricle patients was 7.7 years and 25.2 kg (range: 3 months – 33 years and 8 –80 kg). Most exciting is the first description of Fontan fenestration test occlusion iCMR procedures in  pediatric subjects with complex CHD  with the aid of our EmeryGlide MR conditional guidewire.

 

 

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Live case using EmeryGlide at SCMR (February 14th)

SCMR 2020 is approaching, and interventional MRI live cases are becoming routine in this meeting. On February 14th 2020 the Dallas Children’s team headed by dr Suren Reddy and dr Tarique Hussain will perform an intervention, which will be broadcasted and commented in Orlando by a panel of interventional specialists headed by prof. Gerald Greil. Nano4Imaging and NuMed for children are co-sponsoring this event, and we will also offer live broadcast to Europe for our clients. If you are interested to participate this (late-night: 9:45-10:40 pm CET) webinar please send a mail to paul.borm@nano4imaging.com, clinical director.

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Looking back and forward

At the end of each year it is always good to look back and appreciate the milestones reached, new clients, new procedures and thank all the people and partners who have helped to come us all this way. It is also a tradition to do this graphically and illustrate our achievements and pathways in a postcard, designed by GrabaWeb. Our Horizon 2020 is to extend market use of interventional MRI (join also new LinkedIn group) and bring our hemin MRI contrast agent to the next level. On behalf of the entire N4I team:

Xmas card 2019

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