Goodbye to Ficks law

It has always been  assumed but never proven that iCMR gives an incremental value by providing more accurate flow quantification. In  Dallas Childrens/UTSW interventional MRI is now standard procedure in young adults. Therefore they conducted a study in 30 patients with CHD and conducted both right and left heart cath at a success rate of multiple data points of 98 %. In doing the study the Dallas team  validates hemodynamic measurements obtained via iCMR and showed that iCMR-derived flows have considerably higher test–retest reliability for Qs. iCMR evaluations allow for more reproducible hemodynamic assessments in the CHD population. Goodbye to Fick’s law in CHD

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Proud to receive ECR award

Over the past months the research projects we are involved in, are popular in awards. I guess a recognition for the work done in collaboration with our partners such as Fraunhofer MEVIS, UKSH, Dallas Childrens and many others. Most recently the work to extend our MagnaFy technology to visualize instruments both in MRI and MPI (Magnetic Particle Imaging) within the IMAGINE project was awarded the best research presentation abstract at the European Congress of Radiology2021. Although MPI is still a long way from clinical application, our technology will help to advance its implementation in the future.

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The upside of lockdown

2020 was a year when many things changed in the world and of course also to Nano4Imaging. We started the year with high hopes of successfully launching the EmeryGlide in the USA. However, the pandemic turned everything upside down. Just before that there was the first live case with interventional MRI at SCMR-Orlando out of Dallas Children’s/UTSW, and at the end of the year a 3-years shelf life extension. After the massive global lockdown we were able to secure our financial stability and at the same time have been able to brainstorm a new way forward or a new company role in interventional MRI.

Since many clinical teams had to interrupt their routine and had time to discuss and think about the future and new applications of interventional MRI, we had the opportunity to brainstorm during Zoom, Teams and all the other program-sessions about needs and opportunities. Both existing and new clinical relationships contributed in developing a vision how standard clinical interventions in adults such as angioplasty, aneurysm repair and EVAR could be be enabled in MRI. Meanwhile several project applications with new and renowned partners such as AMC Amsterdam, RUMC Nijmegen, CHIV Lausanne and UKSK in Kiel.

We also realize that many of you have been directly or indirectly affected by COVID-19 and would like to share our thoughts and feelings in this period which has been and is still challenging us on a global level. Wish you relaxing Xmas days with your beloved and hoping to “see” you soon in 2021,




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Interventional MRI: the future

Several events in past weeks demonstrated that MRI is both a new kid on the block as well as serious party for the future. During PICS in Boston (September 13th 2020) dr Alain Nugent (Chicago, Lurie’s Children’s) stated that in 20 years MRI is the standard in the cathlab. The comparison he made was with the Iphone: nobody had one until 15 years ago! His arguments were clear and concerned the absence of radiation, visibility of the target tissue and superior flow measurement by MRI. Early October 2020 during ESMRMB Daniel Hoinkiss received a certificate of Merit award for his poster presentation  which originated from our Eurostars-SPECTRE and used animal data generated in Dallas Children’s by dr Suren Reddy and his team. Even in difficult pandemic times progress is made in our interventional dream.



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Dallas interventional work in complex CHD now in JCMR

It takes time to publish during clinical routine, but finally the groundbreaking work of the team by drs Reddy, Hussain and Greil at Dallas Children’s/UTSW is now published in JCMR. The study describes interventional CMR procedures successfully performed to completion in 31/34 (91%) subjects between August 1st 2017 to December 13th, 2018. Median age and weight of mostly (n=21) single ventricle patients was 7.7 years and 25.2 kg (range: 3 months – 33 years and 8 –80 kg). Most exciting is the first description of Fontan fenestration test occlusion iCMR procedures in  pediatric subjects with complex CHD  with the aid of our EmeryGlide MR conditional guidewire.



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Live case using EmeryGlide at SCMR (February 14th)

SCMR 2020 is approaching, and interventional MRI live cases are becoming routine in this meeting. On February 14th 2020 the Dallas Children’s team headed by dr Suren Reddy and dr Tarique Hussain will perform an intervention, which will be broadcasted and commented in Orlando by a panel of interventional specialists headed by prof. Gerald Greil. Nano4Imaging and NuMed for children are co-sponsoring this event, and we will also offer live broadcast to Europe for our clients. If you are interested to participate this (late-night: 9:45-10:40 pm CET) webinar please send a mail to, clinical director.

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Looking back and forward

At the end of each year it is always good to look back and appreciate the milestones reached, new clients, new procedures and thank all the people and partners who have helped to come us all this way. It is also a tradition to do this graphically and illustrate our achievements and pathways in a postcard, designed by GrabaWeb. Our Horizon 2020 is to extend market use of interventional MRI (join also new LinkedIn group) and bring our hemin MRI contrast agent to the next level. On behalf of the entire N4I team:

Xmas card 2019

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CMR as routine diagnostic for PH

A recent paper in JCMR  (Knight et al, 2019) put online on september 9th shows the feasibility of CMR in routine screening for pulmonary hypertension. Fifty patients were investigated for suspected  or known PH underwent right heart cath in the CMR. Durations of separate procedural components were recorded, including time taken to pass the catheter from the femoral vein to a stable wedge position (procedure time) and total time the patient spent in the CMR department (department time). The study shows that after initial learning and optimization,total department time per patient was under 60 min, and 3-4 patients can be completed in one afternoon. Therefore the procedure is now routine making the extra visit to the cathlab redundant. A win-win for patient and hospital.

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Breakfast workshop PICS shows iCMR is stepping up


On September 6th during the annual PICS symposium Nano4Imaging LLC, BBraun Interventional Systems and pfm medical ag  organized a 2nd breakfast workshop on iCMR in congenital heart disease. The meeting was attended by about 25 clinicians and again showed the strong drive among pediatric centers to move interventional procedures into the MRI. During the workshop drs Reddy (Dallas Children’s) and Ratnayaka (Rady’s Children’s San Diego) shared their experience with MRI guidance. The exchange following their presentations showed that many centers want to move into these procedures, but run into practical and logistic problems with platform suppliers or internal IRB applications. The workshop was also the product launch of the EmeryGlide guidewire by BBraun, and follow-up of last years discussion on clinical indications and medical devices needed to extend the current arena of iCMR.

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